Django

Django is a high-level Python web framework that encourages rapid development and clean, pragmatic design. It comes with an admin panel, authentication system, database abstraction layer, and more, supporting multiple database backends. Django emphasizes the DRY (Don't Repeat Yourself) principle to reduce repetition in web development, making it ideal for building complex, data-driven websites.

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Flask

Flask is a lightweight WSGI web application framework designed to be simple and extensible, allowing developers to add functionality as needed. It's perfect for small projects or microservices architectures. While its core is minimal, Flask becomes powerful through various extensions, supporting features like form validation and file uploads.

FastAPI

FastAPI is a modern, fast (high-performance) web framework for building APIs with Python 3.7+ based on type hints. Designed to be easy to use and capable of automatically generating interactive API documentation, FastAPI is known for its speed—one of the fastest Python web frameworks available. It also offers strong editor support to minimize coding errors and enhance productivity.

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Tornado is a Python web framework and asynchronous networking library especially suited for long polling, WebSockets, and other applications requiring long-lived connections. A key feature of Tornado is its non-blocking network I/O, which makes it excel at handling many concurrent connections, making it suitable for real-time web services.